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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Coagulation abnormalities in osteonecrosis and bone marrow edema syndrome
Patrick Orth1, Konstantinos Anagnostakos
1Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Saar, Germany.
Orthopedics
|April 18, 2013
Summary
This review identifies thrombophilic and hypofibrinolytic markers as potential risk factors for osteonecrosis and bone marrow edema syndrome. Coagulation abnormalities may significantly contribute to the development of these conditions.
Area of Science:
- Medical research
- Hematology
- Orthopedics
Background:
- Osteonecrosis and bone marrow edema syndrome are debilitating conditions.
- The exact etiology of these syndromes is not fully understood.
- Identifying risk factors is crucial for prevention and treatment.
Purpose of the Study:
- To review thrombophilic and hypofibrinolytic markers associated with osteonecrosis and bone marrow edema syndrome.
- To synthesize findings from multiple studies on these risk factors.
- To explore the role of coagulation abnormalities in these bone conditions.
Main Methods:
- Systematic review of 45 studies.
- Inclusion of data from 2163 patients.
- Identification and analysis of 48 different parameters.
Main Results:
- Frequently reported findings include altered lipoprotein concentrations.
- Decreased concentration and function of fibrinolytic agents were noted.
- Increased thrombophilic markers and single nucleotide polymorphisms were identified.
Conclusions:
- Coagulation abnormalities appear to be significant risk factors.
- These findings suggest a link between thrombophilia/hypofibrinolysis and bone conditions.
- Further research is warranted to clarify the precise mechanisms.
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