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Updated: May 12, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Current approaches to the treatment of head injury in children
Chih-Fen Hu1, Hueng-Chuen Fan, Cheng-Fu Chang
1Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Insights
Head trauma requires prompt clinical attention. This review covers traumatic brain injury cases, therapies, and neuroprotective strategies, focusing on outcomes in children.
Area of Science:
- Traumatology
- Neuroscience
- Pediatrics
Background:
- Head trauma presents diagnostic challenges due to variable symptoms across age groups.
- Causes include falls, sports, abuse in children, and traffic accidents in adolescents/adults.
- Injuries range from facial structures to cranial and intracranial damage, including closed and penetrating types.
Purpose of the Study:
- To review traumatic brain injury (TBI) cases.
- To summarize current therapies and neuroprotective strategies for TBI.
- To analyze outcomes for children with TBI.
Main Methods:
- Literature review of traumatic brain injury cases.
- Synthesis of current therapeutic interventions.
- Analysis of neuroprotective strategies and patient outcomes.
Main Results:
- Head trauma management necessitates immediate intervention by clinicians.
- Timely diagnosis and appropriate treatment are critical for life-threatening head and neck injuries.
- The review focuses on diverse TBI presentations and management approaches.
Conclusions:
- Effective management of head trauma is crucial for patient outcomes.
- Neuroprotective strategies play a vital role in TBI treatment.
- Further research on pediatric TBI outcomes is essential.
Abstract:
Head trauma is one of the most challenging fields of traumatology and demands immediate attention and intervention by first-line clinicians. Symptoms can vary from victim to victim and according to the victim's age, leading to difficulties in making timely and accurate decisions at the point of care. In children, falls, accidents while playing, sports injuries, and abuse are the major causes of head trauma. Traffic accidents are the main cause of disability and death in adolescents and adults. Injury sites include facial bones, muscles, ligaments, vessels, joints, nerves, and focal or whole-brain injuries. Of particular importance are cranial and intracranial injuries. A closed injury occurs when the head suddenly and violently hits an object but the object does not break through the skull. A penetrating injury occurs when an object pierces the skull and affects the brain tissue. Early diagnosis and proper management are crucial to treat patients with potentially life-threatening head and neck trauma. In this review, we discuss the different cases of traumatic brain injury and summarize the current therapies and neuroprotective strategies as well as the related outcomes for children with traumatic brain injury.
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