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Updated: May 12, 2026

A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
Published on: May 26, 2023
The relationship between foveal short-wavelength-sensitive visual function and macular pigment optical density in the
1Vision Science Research Group, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom. r.beirne@ulster.ac.uk
Abstract:
To investigate the role of macular pigment in preserving foveal short-wavelength-sensitive (SWS) visual function in the ageing eye orientation identification acuity was measured in the fovea and at 12° eccentricity (nasal visual field) under SWS-cone isolating conditions in 73 participants (aged 20-71). Macular pigment optical density (MPOD) was measured at 0.5° eccentricity from the foveal centre using a heterochromatic flicker photometry (HFP) based instrument. MPOD was not significantly related to age but reduced SWS orientation identification acuity was associated with increasing age in the fovea and at 12° eccentricity. The rate at which foveal acuity changed in relation to acuity at 12° with increasing age was not significantly related to macular pigment levels. These findings do not support the hypothesis that higher macular pigment levels protect S-cone mediated foveal visual function in the ageing eye.
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