Postprandial lipaemia and vascular disease
Genovefa Kolovou1, Teik Chye Ooi
1Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece. genovefa@kolovou.com
Current Opinion in Cardiology
|April 18, 2013
Summary
Postprandial lipemia (PPL), the changes in blood lipids after eating, is linked to vascular disease. Measuring triglyceride levels after meals, not just when fasting, better predicts cardiovascular risk.
Area of Science:
- Cardiovascular Medicine
- Metabolic Research
Background:
- Postprandial lipemia (PPL) involves dynamic changes in serum lipids and lipoproteins after meals.
- Elevated PPL is increasingly recognized as a contributor to vascular disease pathogenesis.
Purpose of the Study:
- To review the pathophysiological mechanisms of PPL in vascular disease.
- To examine evidence linking PPL to vascular disease.
- To discuss factors influencing PPL.
Main Methods:
- Review of current literature on postprandial lipemia and vascular disease.
- Analysis of studies comparing fasting and non-fasting lipid levels as cardiovascular risk predictors.
Main Results:
- Non-fasting triglyceride levels are superior predictors of cardiovascular risk compared to fasting levels.
- Efficient handling of triglyceride-rich lipoproteins post-meal is crucial for vascular health.
Conclusions:
- Postprandial serum triglyceride levels are more effective predictors of vascular disease than fasting levels.
- Measuring triglyceride-rich lipoproteins postprandially captures proatherogenic changes missed in the fasting state.
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