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Major Somatic Sensory Pathways

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...

Sensory Perception: Organization of the Somatosensory System

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The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
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Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.

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Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
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Related Experiment Video

Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Multisensory integration in migraine.

Todd J Schwedt¹

¹Department of Neurology, Mayo Clinic, Phoenix, Arizona 85054, USA. schwedt.todd@mayo.edu

Current Opinion in Neurology

|April 18, 2013

Summary

Migraine involves hypersensitivity to multiple stimuli, suggesting multisensory integration plays a key role in migraine attacks and symptoms. Understanding this brain processing is crucial for migraine pathophysiology.

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Published on: July 29, 2021

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Last Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Area of Science:

Neuroscience
Neurology
Sensory Processing

Background:

Migraine attacks are characterized by head pain and heightened sensitivity to various sensory inputs.
The migraine brain's processing of simultaneous stimuli is not fully understood.

Purpose of the Study:

To investigate how the migraine brain processes and responds to multiple sensory stimuli simultaneously.
To explore the role of multisensory integration in migraine pathophysiology and symptoms.

Main Methods:

This review synthesizes current research on sensory processing in migraine.
Analysis of studies examining responses to somatosensory, visual, auditory, and olfactory stimuli.

Main Results:

Hypersensitivity to one stimulus type correlates with hypersensitivity to others and headache intensity.
Visual, auditory, and olfactory stimuli can trigger migraine attacks.
Evidence suggests a significant role for multisensory integration in migraine.

Conclusions:

Multisensory integration is a critical concept for understanding migraine.
The migraine brain's simultaneous processing of diverse stimuli is key to its pathophysiology.