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Published on: February 21, 2015
Molecular findings in Beckwith-Wiedemann syndrome
Sanaa Choufani1, Cheryl Shuman, Rosanna Weksberg
1Research Institute of the Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Abstract:
Our understanding of Beckwith-Wiedemann syndrome (BWS) has recently been enhanced by advances in its molecular characterization. These advances have further delineated intricate (epi)genetic regulation of the imprinted gene cluster on chromosome 11p15.5 and the role of these genes in normal growth and development. Studies of the molecular changes associated with the BWS phenotype have been instrumental in elucidating critical molecular elements in this imprinted region. This review will provide updated information on the multiple new regulatory elements that have been recently found to contribute to in cis or in trans control of imprinted gene expression in the chromosome 11p15.5 region and the clinical expression of the BWS phenotype.
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