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Evaluation of methicillin-resistant Staphylococcus aureus nasal carriage in Malagasy patients

Tsiry Rasamiravaka1, Saida Rasoanandrasana, Norosoa Julie Julie Zafindraibe

  • 1Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar. travaka@yahoo.fr

Journal of Infection in Developing Countries
|April 18, 2013
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage is high in Madagascar. This study found a significant prevalence of MRSA and multidrug-resistant strains, highlighting the need for control strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of infections globally.
  • Nasal carriage of Staphylococcus aureus is a known risk factor for infection, but data from Madagascar were lacking.

Purpose of the Study:

  • To investigate the prevalence of Staphylococcus aureus and MRSA nasal carriage in Madagascar.
  • To identify risk factors for nasal carriage and assess antibiotic resistance patterns.

Main Methods:

  • Nasal swabs were collected from 304 patients at a Malagasy medical laboratory.
  • Cultures were performed to identify methicillin-sensitive S. aureus (MSSA) and MRSA.

Main Results:

  • Staphylococcus aureus nasal carriage was found in 38.16% of patients, with MRSA identified in 14.80%.
  • History of hospitalization with antibiotic use was a risk factor for MSSA carriage (OR 2.25).
  • MRSA isolates showed high resistance to trimethoprim-sulfamethoxazole (68.89%), erythromycin (66.67%), and ofloxacin (53.33%).

Conclusions:

  • Madagascar exhibits a high prevalence of MRSA nasal carriage and significant multidrug resistance.
  • Strategic policies are needed to combat the spread of multidrug-resistant strains.

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