Related Experiment Video
Updated: May 12, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Joint modeling of multivariate longitudinal measurements and survival data with applications to Parkinson's disease
1Division of Biostatistics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Abstract:
In many clinical trials, studying neurodegenerative diseases including Parkinson's disease (PD), multiple longitudinal outcomes are collected in order to fully explore the multidimensional impairment caused by these diseases. The follow-up of some patients can be stopped by some outcome-dependent terminal event, e.g. death and dropout. In this article, we develop a joint model that consists of a multilevel item response theory (MLIRT) model for the multiple longitudinal outcomes, and a Cox's proportional hazard model with piecewise constant baseline hazards for the event time data. Shared random effects are used to link together two models. The model inference is conducted using a Bayesian framework via Markov Chain Monte Carlo simulation implemented in BUGS language. Our proposed model is evaluated by simulation studies and is applied to the DATATOP study, a motivating clinical trial assessing the effect of tocopherol on PD among patients with early PD.
Related Concept Videos
Parametric Survival Analysis: Weibull and Exponential Methods
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Assumptions of Survival Analysis
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time until a...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Cancer Survival Analysis
Longitudinal Studies
