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Models of a dual inheritance system.

J Maynard Smith1

  • 1School of Biological Sciences, University of Sussex, Brighton, U.K.

Journal of Theoretical Biology
|March 8, 1990
PubMed
Summary

Higher organisms possess dual inheritance systems: DNA sequence and epigenetic gene activation. Occasionally, epigenetic changes transmit through sexual reproduction, impacting evolution.

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Developmental biology

Background:

  • Organisms utilize two primary inheritance systems: DNA sequence-based and epigenetic gene activation.
  • Epigenetic inheritance typically governs developmental states within generations.
  • Transmission of epigenetic information across sexual generations is infrequent but occurs.

Purpose of the Study:

  • To present a formal model of the dual inheritance system.
  • To analyze the conditions under which the separation between DNA and epigenetic inheritance breaks down.
  • To discuss the evolutionary implications of these breakdowns.

Main Methods:

  • Development of a formal mathematical model for dual inheritance.
  • Analysis of model parameters to identify conditions for system breakdown.
  • Theoretical discussion of evolutionary consequences.

Main Results:

  • Demonstration that the separation between DNA and epigenetic inheritance is not absolute.
  • Identification of scenarios where epigenetic changes can be transmitted sexually.
  • The model provides a framework for understanding the interplay between the two systems.

Conclusions:

  • The dual inheritance system can experience breakdowns, allowing epigenetic information to cross sexual generations.
  • Such breakdowns have significant evolutionary implications, potentially accelerating adaptation.
  • Understanding these breakdowns is crucial for a complete picture of inheritance and evolution.

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