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Updated: May 12, 2026
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Tissue-engineered cultured periosteum sheet application to treat infrabony defects: case series and 5-year results
Kazuhiro Okuda1, Tomoyuki Kawase, Masaki Nagata
1Department of Oral Biological Science, Division of Periodontology, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan. okuda@dent.niigata-u.ac.jp
Abstract:
One-year data after autologous grafting of infrabony periodontal defects with human cultured periosteum sheets in combination with platelet-rich plasma and hydroxyapatite granules have shown favorable clinical and radiographic results. A 5-year follow-up evaluation of 22 selected patients indicated that treated infrabony defects remained stable. Radiographically, there was an increase in osseous radiopacity and bone trabeculation suggesting further bone maturation. This novel tissue-engineered periodontal treatment approach has resulted in significant clinical improvement, and defects remained stable after 5 years.
