Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Evaluation of Mechanical Fat Processing Devices: Impact on Adipocytes and Adipose-Derived Stem Cells.

Stem cells international·2026
Same author

Endodontic-sinus communications: a 10-year retrospective observational study on maxillary posterior teeth.

Clinical oral investigations·2026
Same author

First-in-Class Covalent Inhibitors of PFKFB3: Discovery and Characterization in PDAC Models.

Journal of medicinal chemistry·2026
Same author

Influence of Reduced Cortical Bone Compression by Implant Macrogeometry on Peri-Implant Bone Healing: An In Vitro and In Vivo Experimental Study.

Journal of functional biomaterials·2026
Same author

Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy.

Journal of enzyme inhibition and medicinal chemistry·2026
Same author

Electrochemotherapy Treatment for Squamous Cell Carcinoma of the Lip: A Case Report.

International medical case reports journal·2026

Related Experiment Video

Updated: May 12, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Magnesium-substituted hydroxyapatite grafting using the vertical inlay technique.

Pietro Felice1, Giuseppe Lizio, Claudio Marchetti

  • 1Department of Oral and Dental Sciences, University of Bologna, Bologna, Italy. pietro.felice@unibo.it

The International Journal of Periodontics & Restorative Dentistry
|April 18, 2013
PubMed
Summary

Magnesium-substituted hydroxyapatite effectively reconstructed a severely atrophic mandible. This bone grafting material facilitated significant vertical bone gain for dental implant placement.

More Related Videos

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Related Experiment Videos

Last Updated: May 12, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells
06:05

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Area of Science:

  • Oral and Maxillofacial Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Severe mandibular atrophy presents challenges for dental implant rehabilitation.
  • Autogenous bone grafts have limitations, driving the need for effective alloplastic materials.
  • Magnesium-substituted hydroxyapatite (Mg-HA) shows promise as a bone graft substitute.

Purpose of the Study:

  • To evaluate the efficacy of inlay Mg-HA grafting for reconstructing a severely atrophic posterior mandible.
  • To assess bone regeneration and implant osseointegration following Mg-HA grafting.

Main Methods:

  • A severely atrophic left posterior mandible was reconstructed using the inlay technique with Mg-HA.
  • Bone specimen retrieval and dental implant placement were performed three months post-grafting.
  • Histologic analysis examined bone-implant contact and graft incorporation.

Main Results:

  • A mean vertical bone gain of 4.9 mm was achieved at implant placement.
  • Successful delivery of provisional and definitive prostheses occurred at 4 and 8 months, respectively.
  • Histology confirmed newly formed bone infiltrating the residual Mg-HA graft material.

Conclusions:

  • Mg-HA is an effective bone grafting material for posterior mandibular reconstruction via the inlay technique.
  • This clinical case demonstrates successful bone regeneration and implant osseointegration using Mg-HA.
  • Mg-HA offers a viable alternative for treating severe mandibular defects requiring augmentation for dental implants.