Related Experiment Video
Updated: May 12, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
Commentary on headache currents articles by Alhazzani and Goddeau
1Division of Developmental Disabilities, Nebraska Department of Health and Human Services, Lincoln, Nebraska, USA.
Insights
Headaches can signal cerebrovascular disease, especially hemorrhagic types. Migraine with aura may increase stroke risk, with links to cerebrovascular disease being causal, coincidental, or co-morbid.
Area of Science:
- Neurology
- Vascular Neurology
Background:
- Headache is a recognized symptom associated with cerebrovascular diseases.
- Specific headache disorders, such as migraine with aura, are increasingly linked to stroke risk.
Purpose of the Study:
- To explore the complex relationship between headache disorders and cerebrovascular diseases.
- To elucidate the potential causal, coincidental, or co-morbid nature of these associations.
Main Methods:
- Literature review and synthesis of existing research on headache and cerebrovascular events.
- Analysis of epidemiological data and clinical case studies.
Main Results:
- Headache is a prominent symptom in hemorrhagic cerebrovascular disease.
- Migraine with aura is identified as a significant risk factor for both ischemic and potentially hemorrhagic stroke.
Conclusions:
- The association between migraine and cerebrovascular disease is multifaceted, encompassing causal, coincidental, and co-morbid pathways.
- Understanding these links is crucial for accurate diagnosis and risk stratification in patients presenting with headache.
Abstract:
Headache is a symptom of cerebrovascular disease, particularly the hemorrhagic type. Also, certain headache types, notably migraine with aura, predispose individuals to ischemic and perhaps hemorrhagic stroke. The relationship between migraine and cerebrovascular disease can be causal, coincidental or co-morbid.
Related Concept Videos
Glaucoma: Overview
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
Increased Intracranial Pressure l: Introduction
Veins of Head and Neck
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Increased Intracranial Pressure ll: Pathophysiology
