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Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010)
Ramnath Misra1, Debashish Danda, Sivakumar M Rajappa
1Department of Clinical Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India. rnmisra2000@gmail.com, rnmisra@sgpgi.ac.in.
Rheumatology (Oxford, England)
|April 19, 2013
Summary
A new tool, the Indian Takayasu Clinical Activity Score (ITAS2010), effectively measures disease activity in Takayasu arteritis (TA). This validated score helps monitor patient progress and identify active disease.
Area of Science:
- Rheumatology
- Vascular Inflammation
- Clinical Assessment Tools
Background:
- Takayasu arteritis (TA) lacks validated instruments for measuring disease activity.
- Accurate assessment is crucial for effective patient management and monitoring treatment response.
Purpose of the Study:
- To develop and validate the Indian Takayasu Clinical Activity Score (ITAS2010) for assessing clinical disease activity in TA.
- To evaluate the score's reliability, validity, and sensitivity to change.
Main Methods:
- The ITAS was derived from existing disease indices and validated by expert physicians.
- Inter-rater reliability (IRR), convergence with other measures (BVAS, PGA), and correlation with acute phase reactants (ESR/CRP) were assessed.
- A single-center study validated the ITAS2010 in 177 TA patients for discriminating active vs. inactive disease and its sensitivity to change in 132 patients.
Main Results:
- The ITAS2010 comprises 44 items, with 33 related to cardiovascular manifestations.
- High inter-observer reliability (IRR 0.97) was demonstrated, outperforming BVAS and PGA.
- The ITAS2010 scores were significantly higher in active disease compared to inactive disease (P < 0.0001) and showed sensitivity to therapeutic changes.
Conclusions:
- The ITAS2010 is a validated and sensitive tool for monitoring clinical disease activity in Takayasu arteritis patients.
- Elevated ITAS-A scores indicate potential inadequacy of current therapies in controlling active disease.
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