Related Experiment Video
Updated: May 12, 2026

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
Published on: August 30, 2011
Visual motion event related potentials distinguish aging and Alzheimer's disease
Roberto Fernandez1, Anthony Monacelli, Charles J Duffy
1Departments of Neurology, Brain and Cognitive Sciences, Neurobiology and Anatomy, Ophthalmology, and the Center for Visual Science, The University of Rochester Medical Center, Rochester, NY 14642-0673, USA.
Background:
Aging and Alzheimer's disease (AD) disrupt visuospatial processing and visual motion evoked potentials in a manner linked to navigational deficits.
Objective:
Our goal is to determine if aging and AD have distinct effects on visual cortical motion processing for navigation.
Methods:
We recorded visual motion event related potentials (ERPs) in young (YNC) and older normal controls (ONC), and early AD patients (EADs) who viewed rapidly changing optic flow stimuli that simulate naturalistic changes in heading direction, like those that occur when following a path of self-movement through the environment. After a random series of optic flow stimuli, a vertical motion stimulus was presented to verify sustained visual attention by demanding a rapid push-button response.
Results:
Optic flow evokes robust ERPs that are delayed in aging and diminished in AD. The interspersed vertical motion stimuli yielded shorter N200 latencies in EADs, matching those in ONCs, but the EADs' N200 amplitudes remained small.
Conclusions:
Aging and AD have distinct effects on visual sensory processing: aging delays evoked response, whereas AD diminishes responsiveness.
More Related Videos
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
06:25Motion-Acuity Test for Visual Field Acuity Measurement with Motion-Defined Shapes
Published on: February 23, 2024
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Visual Agnosia