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Related Experiment Video

Updated: May 12, 2026

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

A polymeric waveguide resonant mirror (RM) device for detection in microfluidic flow cells.

Ruchi Gupta1, Nick J Goddard

  • 1School of Chemical Engineering and Analytical Science, Manchester Institute of Biotechnology, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. ruchi.gupta@manchester.ac.uk

The Analyst
|April 19, 2013
PubMed
Summary

Researchers developed a novel resonant mirror (RM) device for sensitive chemical and biological detection. This low-cost, easily mass-produced device offers high sensitivity for absorption spectroscopy and biomolecule binding detection.

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Area of Science:

  • Optoelectronics
  • Biosensing
  • Spectroscopy

Background:

  • Resonant mirror (RM) devices offer label-free detection capabilities.
  • Existing RM devices require complex fabrication or lack versatility.

Purpose of the Study:

  • To develop a novel, low-cost, and easily mass-producible resonant mirror (RM) device.
  • To demonstrate the device's utility in absorption spectroscopy and biomolecular interaction analysis.

Main Methods:

  • Fabrication of a resonant mirror device using silica sol-gel spacer and polystyrene waveguide layers via spin coating.
  • Measurement of methylene blue absorption spectrum.
  • Detection of antibody-antigen binding (anti-IgG and IgG).

Main Results:

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Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
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Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor

Published on: August 30, 2012

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Last Updated: May 12, 2026

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics
09:54

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor
07:28

Terahertz Microfluidic Sensing Using a Parallel-plate Waveguide Sensor

Published on: August 30, 2012

  • Achieved a limit of detection (LOD) of 20.8 μM for methylene blue with a minimum detectable absorption coefficient of 0.94 cm⁻¹.
  • Detected IgG at concentrations as low as 100 nM.
  • Demonstrated high sensitivity (17.27°/RIU) and resolution (1.45 × 10⁻⁴ RIU) for refractive index changes.

Conclusions:

  • The developed RM device is a versatile platform for both absorption spectroscopy and label-free biomolecular detection.
  • The device's simple fabrication and low cost facilitate integration with microfluidic systems for widespread application.
  • This technology enables easy identification and quantification of chemical and biological species.