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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(II) drugs
Haihua Xiao1, Jared F Stefanick, Xiaoyu Jia
1Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
Chemical Communications (Cambridge, England)
|April 19, 2013
Abstract:
Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(II) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.
