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Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors
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Bis[zinc(II)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water

Karen K Y Yuen1, Katrina A Jolliffe

  • 1School of Chemistry, The University of Sydney, 2006, NSW, Australia.

Chemical Communications (Cambridge, England)
|April 19, 2013
PubMed

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Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...