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Related Experiment Video

Updated: May 12, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Quantitative single and multi-surface clinical corneal topography utilizing optical coherence tomography.

Ryan P McNabb¹, Anthony N Kuo, Joseph A Izatt

¹Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, North Carolina 27708, USA. ryan.mcnabb@duke.edu

|April 19, 2013

Summary

Accurate eye astigmatism measurement is key for surgery. New optical coherence tomography (OCT) methods capture both corneal surfaces, improving astigmatism assessment compared to standard techniques.

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Last Updated: May 12, 2026

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Published on: August 9, 2024

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Area of Science:

Ophthalmology
Biomedical Optics
Corneal Imaging

Background:

Accurate measurement of ocular astigmatism magnitude and axis is crucial for successful surgical correction.
Current clinical methods like keratometry and topography primarily analyze the anterior corneal surface.
The posterior cornea also contributes to total corneal astigmatism, but is often unmeasured.

Purpose of the Study:

To present a novel technique combining anterior and posterior corneal surface data for a comprehensive astigmatism assessment.
To evaluate the clinical applicability of this combined pseudosurface for astigmatism measurement.
To validate the accuracy of the proposed method against standard clinical measures.

Main Methods:

Utilized distributed scanning optical coherence tomography (DSOCT) to acquire high-resolution 3D corneal volumes.
Developed a method to combine local curvatures from both anterior and posterior corneal surfaces into a single pseudosurface.
Applied DSOCT to a pilot patient study, analyzing extracted corneal astigmatic power and direction.

Main Results:

The DSOCT technique successfully captured both anterior and posterior corneal surface data.
The combined pseudosurface provided a comprehensive measure of corneal astigmatism.
Extracted astigmatic power and direction values from DSOCT were comparable to standard clinical measurements.

Conclusions:

The presented DSOCT technique offers an advanced method for characterizing ocular astigmatism by including posterior corneal contributions.
This approach has the potential to improve the accuracy of pre-operative astigmatism assessment and surgical planning.
Further clinical validation of this technique is warranted for widespread adoption.