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Jennifer-Lynn Demers1, Scott C Davis, Rongxiao Zhang

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This study demonstrates that Čerenkov light from radiation therapy can image molecular reporters in tissue. This novel approach allows for molecular sensing of tissue response during cancer treatment.

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Area of Science:

  • Medical Physics
  • Optical Imaging
  • Molecular Imaging

Background:

  • Radiation therapy for cancer generates Čerenkov emission.
  • This emission can potentially excite molecular reporters in vivo.
  • Sensing tissue response during fractionated therapy is crucial.

Purpose of the Study:

  • To test the spatial mapping of Čerenkov-excited molecular reporters using tomographic recovery.
  • To evaluate the feasibility of in vivo molecular sensing during fractionated radiotherapy.

Main Methods:

  • Utilized 6 MV photons from a linear accelerator in a heterogeneous tissue phantom.
  • Employed diffuse tomography to recover fluorophore distribution from Čerenkov light.
  • Used spectrometer detection and spectral fitting to differentiate signals.

Main Results:

  • Čerenkov light successfully excited fluorophores throughout the tissue phantom.
  • Fluorescent diffuse tomographic images demonstrated a linear response between concentration and reconstructed values.
  • The method showed potential for molecular imaging applications.

Conclusions:

  • Spatial mapping of Čerenkov-excited molecular reporters is feasible using diffuse tomography.
  • This technique shows promise for molecular imaging during radiotherapy.
  • Further application in treatment with molecular reporters appears promising.