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Updated: May 12, 2026
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
NetworkPrioritizer: a versatile tool for network-based prioritization of candidate disease genes or other molecules
Tim Kacprowski1, Nadezhda T Doncheva, Mario Albrecht
1Max Planck Institute for Informatics, Saarbrücken, Germany.
Summary:
The prioritization of candidate disease genes is often based on integrated datasets and their network representation with genes as nodes connected by edges for biological relationships. However, the majority of prioritization methods does not allow for a straightforward integration of the user's own input data. Therefore, we developed the Cytoscape plugin NetworkPrioritizer that particularly supports the integrative network-based prioritization of candidate disease genes or other molecules. Our versatile software tool computes a number of important centrality measures to rank nodes based on their relevance for network connectivity and provides different methods to aggregate and compare rankings.
Availability:
NetworkPrioritizer and the online documentation are freely available at http://www.networkprioritizer.de
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