Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Breaking the activity-selectivity trade-off in nitrogen-containing volatile organic compounds abatement via NiCu synergistic perovskite catalysts.

Journal of colloid and interface science·2026

Same author

Bone mineral density, prolactin, estradiol, testosterone levels and related research in male chronic patients with schizophrenia.

BMC psychiatry·2026

Same author

Combined Use of Three Endoscopes With Primary Suture of Common Bile Duct and Antegrade Nasobiliary Drainage for Common Bile Duct Stones.

Surgical laparoscopy, endoscopy & percutaneous techniques·2026

Same author

Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women.

Frontiers in endocrinology·2026

Same author

Top-down medial prefrontal cortex-to-hypothalamic paraventricular nucleus circuit regulates social avoidance and conditioned fear in male mice.

Cell discovery·2026

Same author

NEURONpyxl: fast, flexible, Python-integrated simulation of biophysical neural networks with complex plastic synapses.

Frontiers in computational neuroscience·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol.

Rong-Yu Liu¹, Yili Zhang, Douglas A Baxter

¹Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, Houston, Texas 77030, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|April 19, 2013

Summary

Deficits in CREB-binding protein (CBP) impair learning and memory. A computational model identified a novel serotonin (5-HT) pulse protocol to restore long-term synaptic facilitation (LTF) in a model system.

More Related Videos

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

Related Experiment Videos

Last Updated: May 12, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

Area of Science:

Neuroscience
Molecular Biology
Computational Biology

Background:

CREB-binding protein (CBP) mutations are linked to impaired learning and memory.
Long-term synaptic facilitation (LTF) is a cellular model for learning and memory processes.

Purpose of the Study:

To investigate methods for overcoming LTF deficits caused by reduced CBP levels.
To develop and test a computational model for predicting LTF rescue strategies.

Main Methods:

Utilized Aplysia sensorimotor synapses in cell culture to model LTF.
Employed CBP-siRNA to knockdown CBP levels and assess LTF impairment.
Developed a computational model simulating molecular processes of LTF induction.
Tested a predicted rescue protocol using non-uniform serotonin (5-HT) pulse intervals.

Main Results:

CBP knockdown significantly impaired LTF.
The computational model accurately predicted a rescue protocol.
The novel 5-HT pulse protocol successfully restored LTF despite reduced CBP levels.

Conclusions:

Complementary empirical and computational approaches can identify effective interventions for learning impairments.
This study demonstrates a method to ameliorate learning deficits caused by molecular disruptions in CBP.
Findings offer insights into potential therapeutic strategies for cognitive disorders linked to CBP dysfunction.