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Related Experiment Video

Updated: May 12, 2026

Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
07:59

Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol

Published on: September 7, 2018

Canine body composition quantification using 3 tesla fat-water MRI.

Aliya Gifford1, Joel Kullberg, Johan Berglund

  • 1Vanderbilt University Institute of Imaging Science, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Journal of Magnetic Resonance Imaging : JMRI
|April 19, 2013
PubMed
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Whole-body fat-water MRI (FWMRI) precisely quantifies canine body composition. This method accurately measures changes in adipose, lean, and bone tissue mass, offering a valuable tool for metabolic disease research.

Area of Science:

  • Veterinary imaging
  • Body composition analysis
  • Metabolic disease research

Background:

  • Accurate body composition assessment is crucial for understanding metabolic disease.
  • Longitudinal studies require precise methods to track changes in tissue depots.
  • Obesity models in animals are vital for human metabolic disease research.

Purpose of the Study:

  • To validate whole-body fat-water MRI (FWMRI) for precise quantification of adipose, lean, and bone tissue mass in dogs.
  • To assess the agreement between FWMRI-derived mass and scale mass measurements.
  • To evaluate FWMRI's ability to detect diet-induced body composition changes in a longitudinal study.

Main Methods:

  • Six adult male dogs were scanned using FWMRI at baseline and week 4.
Keywords:
adiposebonecaninefat-waterleanwhole-body

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  • Semi-automated image analysis quantified adipose (visceral, subcutaneous, total), lean, and cortical bone tissue volumes.
  • Volumes were converted to masses using established tissue densities.

    • Main Results:

    • FWMRI-derived total mass showed high concordance with scale mass (CCC=0.931).
    • Significant increases in visceral (70.2%), subcutaneous (67.0%), and total adipose tissue mass were observed.
    • Cortical bone and lean tissue masses remained unchanged.

    Conclusions:

    • FWMRI accurately quantifies canine body composition, including distinct tissue depots.
    • The validated FWMRI protocol is a valuable tool for studying metabolic disease in animal models.
    • This technique enables precise tracking of body composition changes relevant to human metabolic disorders.