Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Whole Body Regeneration

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...

Maintenance of the ES Cell State

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimal melanoma treatment protocols: A bilinear control model.

Mathematical biosciences·2026

Same author

Population structure reverses selection of variants with proportionally scaled birth and death rates.

Nature communications·2025

Same author

Author Correction: Barcoded HIV-1 reveals viral persistence driven by clonal proliferation and distinct epigenetic patterns.

Nature communications·2025

Same author

Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations.

PNAS nexus·2025

Same author

The functional form of the association between K-12 student performance and household income in U.S. school districts.

PloS one·2025

Same author

Detecting (the Absence of) Species Interactions in Microbial Ecological Systems.

Studies in applied mathematics (Cambridge, Mass.)·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

Stem cell control, oscillations, and tissue regeneration in spatial and non-spatial models.

Ignacio A Rodriguez-Brenes¹, Dominik Wodarz, Natalia L Komarova

¹Department of Mathematics, University of California Irvine Irvine, CA, USA.

Frontiers in Oncology

|April 19, 2013

Summary

Tissue regulation relies on differentiated cells inhibiting stem cell division. Understanding these cell dynamics is crucial for cancer research, as tumor initiation involves escaping normal tissue control mechanisms.

Keywords:

cancer cell linage control mathematical models tissue regeneration tissue stability

More Related Videos

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Related Experiment Videos

Last Updated: May 12, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Area of Science:

Cell biology
Developmental biology
Cancer biology

Background:

Normal human tissues comprise organized cell lineages originating from stem cells.
Tissue homeostasis and regeneration depend on regulated cell division and feedback loops.
Differentiated cells secrete signals that inhibit stem cell proliferation, maintaining tissue control.

Purpose of the Study:

To investigate the cell dynamics governed by inhibitory feedback from differentiated cells.
To elucidate the fundamental mechanisms underlying tissue regulation and its disruption.

Main Methods:

Detailed study of cell dynamics.
Analysis of feedback control mechanisms in cell lineages.

Main Results:

Identified specific cell dynamics arising from differentiated cell-induced stem cell inhibition.
Demonstrated the critical role of these dynamics in maintaining tissue homeostasis.

Conclusions:

Understanding normal cell regulatory dynamics provides insights into cancer development.
Disruption of these feedback mechanisms is a key step in tumor initiation and progression.