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Published on: February 15, 2020
[Oxidative damage effects induced by CdTe quantum dots in mice liver]
Guangyun Xie1, Qingcheng Du, Min Zheng
1Insititue for Ocuupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China. guangyunxie@163.com
Objective:
To investigate oxidative damage effects induced by CdTe quantum dots (QDs) in mice liver.
Methods:
40 ICR mice were randomly divided into 5 groups, one control group (normal saline), four CdTe QDs (exposed by intravenous injection of 0.2 ml CdTe QDs at the concentration of 0, 0.5, 5, 50 and 500 nmol/ml respectively). All mice were decapitated 24h after the injection. Concentration of MDA and the activities of SOD, CAT, 8-OHdG expression were examined by immunohistochemistry and hepatocellular apoptosis was measured with TUNEL resperctively.
Results:
The results showed in 500 nmol/ml CdTe QDs group, MDA concentration in the liver tissue were significantly higher than those of control group (P < 0.05). The activities of SOD in 50 and 500 nmol/ml and CAT in 5, 50 and 500 nmol/ml CdTe QDs groups were significantly lower than those of control group (P < 0.01). Positive staining for 8-OHdG appeared in 50 and 500 nmol/ml CdTe QDs groups and the apoptosis of liver cells was observed in 500 nmol/ml CdTe QDs group by TUNEL technique.
Conclusion:
It was suggested that CdTe QDs at certain doses could induce oxidative damage effects of the mice liver in the condition of this experiment.
