Related Experiment Video
Updated: May 12, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
[A case-control study on the relationship between organochlorine and female breast cancer]
Hong Zhang1, Lan Liu, Pengju Zhang
1School of Public Health, Ningxia Medical University, Yinchuan 750004, China. lindersy@126.com
Objective:
To describe the serum organochlorines residues and explore the relationship between organochlorines exposure and the female breast cancer in Ningxia.
Methods:
1:1 matched case-control study based on 92 new diagnostic breast cancer patients and 92 patients without tumors from Ningxia medical university general hospital was designed. The risk factors of breast cancer were investigated by a questionnaire. GC-ECD was used to measure the serum level of organochlorines residues. The adjusted odds rations (OR) of organochlorines residues to breast cancer were evaluated by conditional Logistic regression model.
Results:
15 organochlorines residues could be detected in serum of cases and controls. The detecting rates of beta-HCH, delta-HCH, p,p'-DDE, PCB28 and PCB52 were higher than 90%. There were significant differences of serum level of beta-HCH, p,p'-DDE and PCB52 between cases and controls (P < 0.05). After adjusting confounding factors, serum beta-HCH, p,p'-DDE and PCB52 level were positively related to the risk of breast cancer (adjusted OR > 2, P < 0.05).
Conclusion:
Organochlorines resides, including DDT, HCH and PCB, may increase women's risk of getting breast cancer.
Related Concept Videos
Cancer Prevention
Some...
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Disorders of the Female Reproductive System
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Chi-square Analysis
The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...
Oogenesis
