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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
What is the Endocrine System?00:46

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.

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Related Experiment Video

Updated: May 12, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
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Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

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[The endocannabinoid system in obesity].

Zoltan Pataky1, Elisabetta Bobbioni-Harsch, Anne Carpentier

  • 1Centre Collaborateur de I'OMS, Département de Médecine Communautaire, HUG, Genève 14. zoltan.pataky@hcuge.ch

Revue Medicale Suisse
|April 20, 2013
PubMed
Summary

The endocannabinoid system regulates energy balance and appetite. Its overactivity in obesity, particularly with increased abdominal fat, suggests targeting peripheral endocannabinoid effects for new obesity treatments.

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Area of Science:

  • Endocrinology and Metabolism
  • Neuroscience

Context:

  • The endocannabinoid system (ECS) plays a crucial role in regulating energy homeostasis.
  • Endocannabinoids are known to influence appetite and hunger centrally.
  • Components of the ECS are also present in peripheral organs, affecting lipid and glucose metabolism.

Purpose:

  • To explore the role of the endocannabinoid system in energy balance and metabolism.
  • To investigate the link between endocannabinoid system overactivity and obesity.
  • To identify potential therapeutic targets for obesity treatment.

Summary:

  • Obesity is characterized by an overactive endocannabinoid system, evidenced by elevated plasmatic and visceral adipose tissue levels.
  • Increased intra-abdominal fat mass serves as an indicator of peripheral endocannabinoid system dysregulation.
  • Endocannabinoid-like molecules with peripheral metabolic effects present a novel therapeutic avenue for obesity.

Impact:

  • Highlights the dual role of the endocannabinoid system in central appetite regulation and peripheral metabolic processes.
  • Establishes a connection between obesity, endocannabinoid system dysregulation, and abdominal fat accumulation.
  • Proposes a new strategy for obesity treatment by targeting peripheral endocannabinoid pathways.