Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revealing the biomolecular response of glioma cells to helium, carbon and oxygen minibeam radiation therapy using synchrotron-based infrared microspectroscopy.

The Analyst·2026
Same author

Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.

The Analyst·2025
Same author

Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.

The Analyst·2024
Same author

Dosimetric feasibility study ("proof of concept") of refractory ventricular tachycardia radioablation using proton minibeams.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2024
Same author

RadioTransNet, Radiotherapy Translational and Preclinical Research Network: Results from the dedicated French cancer institute (INCa) call for projects.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2023
Same author

Novel unconventional radiotherapy techniques: Current status and future perspectives - Report from the 2nd international radiation oncology online seminar.

Clinical and translational radiation oncology·2023

Related Experiment Video

Updated: May 12, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Monte Carlo-based dose calculation engine for minibeam radiation therapy.

I Martínez-Rovira1, J Sempau2, Y Prezado3

  • 1Service Hospitalier Frédéric Joliot (DSV/I2BM/SHFJ), Commissariat à l'Énergie Atomique et aux énergies alternatives (CEA), 4, Place du Général Leclerc, F-91401 Orsay, France; Institut de Tècniques Energètiques (INTE), Universitat Politècnica de Catalunya (UPC), Diagonal 647, E-08028 Barcelona, Spain; ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), B.P. 220, 6 rue Jules Horowitz, F-38043 Grenoble Cedex, France.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|April 20, 2013
PubMed
Summary

Minibeam radiation therapy (MBRT) utilizes micro-beams for enhanced tissue sparing. A new Monte Carlo dose calculation engine, validated with phantom data, enables efficient treatment planning for MBRT clinical trials.

Keywords:
Minibeam radiation therapyMonte Carlo calculationsSpatially fractionated synchrotron radiotherapy techniquesTreatment planning system

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Experiment Videos

Last Updated: May 12, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

  • Medical Physics
  • Radiotherapy
  • Radiation Oncology

Background:

  • Minibeam radiation therapy (MBRT) leverages the tissue-sparing effects of precisely aligned micro-beams.
  • Preclinical trials are underway to evaluate MBRT's efficacy and safety.

Purpose of the Study:

  • To develop and validate a Monte Carlo-based dose calculation engine for MBRT.
  • To assess the feasibility of MBRT treatment planning for clinical applications.

Main Methods:

  • A Monte Carlo simulation engine was developed for MBRT dose distribution calculations.
  • The engine was benchmarked against experimental data using anthropomorphic phantoms.
  • Treatment planning efficiency was optimized for clinical applicability.

Main Results:

  • The dose calculation engine was successfully benchmarked with experimental data.
  • Acceptable computation times (approx. 2 hours) were achieved for MBRT dose calculations.
  • A realistic MBRT treatment plan example was generated.

Conclusions:

  • The developed Monte Carlo engine is suitable for guiding MBRT preclinical trials.
  • The engine's adaptability allows for use with various synchrotron sources and contrast agents.
  • This tool facilitates the clinical translation of MBRT.