Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Blood Typing

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Management of the blood supply for a Jk(a-b-) patient with an anti-Jk3 in preparation for an urgent heart transplant: An illustrative example of a successful international cooperation.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2018

Same author

Vox Sanguinis International Forum on provision of granulocytes for transfusion and their clinical use: summary.

Vox sanguinis·2017

Same author

Vox Sanguinis International Forum on provision of granulocytes for transfusion and their clinical use.

Vox sanguinis·2017

Same author

[Pediatric preparations of blood products].

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2017

Same author

Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.

British journal of anaesthesia·2012

Same author

[Evolution of indications and consumptions of fresh frozen plasma from 1997 to 2003 in a teaching Hospital].

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2005

Search research articles

Related Experiment Video

Updated: May 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Transfusion and sickle cell disease].

¹Établissement français du sang Île-de-France, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France. Claire.boulat@efs.sante.fr

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine

|April 20, 2013

Summary

This summary is machine-generated.

Sickle cell disease (SCD) management requires tailored transfusion protocols due to alloimmunization risks. Promoting blood donation from individuals of African ancestry is crucial for improving transfusion safety in SCD patients.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: May 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

Hematology
Genetics
Public Health

Background:

Sickle cell disease (SCD) is a hereditary hemoglobinopathy primarily affecting individuals of African ancestry.
The prevalence of SCD is increasing in France, necessitating optimized treatment strategies.
Blood transfusion is a cornerstone therapy for managing SCD complications.

Purpose of the Study:

To highlight the challenges in transfusion management for SCD patients, particularly concerning alloimmunization.
To emphasize the need for adapted transfusion protocols considering patient history and donor-recipient genetic disparities.
To underscore the importance of increasing blood donation from African ancestry populations.

Main Methods:

Review of current transfusion practices and challenges in SCD.
Analysis of alloimmunization incidence in SCD patients receiving transfusions.
Discussion of strategies to enhance transfusion safety.

Main Results:

SCD patients face a high risk of alloimmunization due to genetic variations in blood group antigens compared to European donors.
Standard transfusion protocols may be inadequate, requiring adjustments for polytransfused individuals.
Manual and automated exchange transfusion methods are employed, each with specific considerations.

Conclusions:

Optimizing transfusion safety in SCD requires addressing alloimmunization through careful donor selection and protocol adaptation.
Increasing the pool of compatible blood donors from African ancestry is a critical first step.
Further development of strategies to mitigate transfusion risks in this growing patient population is essential.