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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
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Updated: May 12, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Relapsing polychondritis.

Ratnesh Chopra1, Nida Chaudhary, Jonathan Kay

  • 1Rheumatology Center, Memorial Campus, UMass Memorial Medical Center, 119 Belmont Street, Worcester, MA 01605, USA.

Rheumatic Diseases Clinics of North America
|April 20, 2013
PubMed
Summary
This summary is machine-generated.

Relapsing polychondritis (RP) is a rare autoimmune disease causing cartilage destruction. Treatments range from corticosteroids to immunosuppressants, with biologics showing potential for severe cases.

Related Experiment Videos

Last Updated: May 12, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Systemic Autoimmune Diseases

Background:

  • Relapsing polychondritis (RP) is a rare systemic autoimmune disease.
  • Characterized by episodic, progressive inflammatory destruction of cartilage.
  • Can present as an overlap syndrome with other rheumatologic conditions.

Purpose of the Study:

  • To summarize the characteristics and treatment of relapsing polychondritis.
  • To highlight the varied disease course and management strategies.
  • To explore potential novel therapeutic options.

Main Methods:

  • Literature review of relapsing polychondritis.
  • Analysis of disease progression and clinical manifestations.
  • Overview of current and emerging treatment modalities.

Main Results:

  • RP typically follows an indolent relapsing-remitting course but can progress rapidly.
  • Mild cases (e.g., chondritis, peripheral arthritis) often respond to low-dose corticosteroids.
  • Severe manifestations necessitate high-dose corticosteroids or immunosuppressive agents.

Conclusions:

  • Treatment for RP is guided by disease severity and organ involvement.
  • Established therapies include corticosteroids and immunosuppressants.
  • Biological targeted therapies represent a promising avenue for managing severe RP.