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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Updated: May 12, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

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Published on: June 10, 2025

Whipple's disease.

Sergio Schwartzman1, Monica Schwartzman

  • 1Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, USA. SchwartzmanS@HSS.EDU

Rheumatic Diseases Clinics of North America
|April 20, 2013
PubMed
Summary
This summary is machine-generated.

Whipple's disease, caused by Tropheryma whipplei, presents with diverse symptoms affecting multiple organ systems. Early diagnosis via tissue analysis and prompt antibiotic treatment offer a potential cure, though recurrence is possible.

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Area of Science:

  • Infectious Diseases
  • Microbiology
  • Rheumatology

Background:

  • Whipple's disease is a rare, chronic, systemic infectious disease.
  • It is caused by the bacterium Tropheryma whipplei.
  • The disease is characterized by a wide range of clinical manifestations, often involving the gastrointestinal tract, musculoskeletal system, and central nervous system.

Purpose of the Study:

  • To provide a comprehensive review of Whipple's disease.
  • To cover its microbiology, pathophysiology, epidemiology, clinical features, diagnosis, and treatment.
  • To highlight key aspects for clinicians and researchers.

Main Methods:

  • Literature review of existing studies on Whipple's disease.
  • Analysis of diagnostic methods, including periodic acid-Schiff staining and polymerase chain reaction (PCR).
  • Evaluation of current therapeutic strategies and outcomes.

Main Results:

  • Tropheryma whipplei is the causative agent, identified through tissue sampling.
  • Clinical manifestations are diverse, commonly affecting the GI tract, joints, CNS, heart, and eyes.
  • Diagnosis is confirmed by PAS staining and/or PCR on tissue samples.
  • Antibiotic therapy is effective, offering potential cure but with a risk of recurrence.

Conclusions:

  • Whipple's disease requires a high index of suspicion due to its varied presentation.
  • Accurate diagnosis relies on specific laboratory and histological findings.
  • Effective antibiotic treatment can lead to remission, but long-term monitoring is essential to manage potential recurrences.