Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Wound Recovery in Amniotic Band Syndrome Via Personalized 3D Biomodels: The Case of the Ballet Dancer.

Advances in skin & wound care·2026
Same author

Prospective evaluation of recombinant Herpes zoster vaccine in SSc: immunogenicity, safety and disease outcomes.

Rheumatology (Oxford, England)·2026
Same author

Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features.

Seminars in arthritis and rheumatism·2026
Same author

Vitamin E in dermatology.

Clinics in dermatology·2026
Same author

Recombinant herpes zoster vaccine in patients with autoimmune rheumatic diseases in Brazil: a double-blind, randomised, placebo-controlled, phase 4, non-inferiority study.

The Lancet. Rheumatology·2026
Same author

Frequency of HLA class I and II in an admixed Brazilian population with psoriasis.

Anais brasileiros de dermatologia·2026
Same journal

Bridging the Divide in Global Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Foreword.

Rheumatic diseases clinics of North America·2026
Same journal

Pulmonary Complications of Biological Therapies in Inflammatory and Autoimmune Diseases.

Rheumatic diseases clinics of North America·2026
Same journal

Artificial Intelligence and Social Determinants of Health.

Rheumatic diseases clinics of North America·2026
Same journal

Updates in Ultrasound in Rheumatology.

Rheumatic diseases clinics of North America·2026
Same journal

Health Systems Strengthening to Promote Access to Care for Rheumatic and Musculoskeletal Diseases Globally.

Rheumatic diseases clinics of North America·2026
See all related articles

Related Experiment Videos

SAPHO syndrome.

Sueli Carneiro1, Percival D Sampaio-Barros

  • 1State University of Rio de Janeiro - Rua Farme de Amoedo 140/601, Ipanema, Rio de Janeiro 22420-020, Brazil.

Rheumatic Diseases Clinics of North America
|April 20, 2013
PubMed
Summary
This summary is machine-generated.

SAPHO syndrome, a condition involving synovitis, acne, pustulosis, hyperostosis, and osteitis, presents diagnostic challenges due to varied symptoms. Early clinical and imaging evaluation is crucial for accurate diagnosis and management.

Related Experiment Videos

Area of Science:

  • Rheumatology
  • Dermatology
  • Immunology

Background:

  • SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) is a rare autoinflammatory disorder.
  • Its diagnosis is challenging due to non-simultaneous presentation of osteoarticular and skin symptoms and lack of validated criteria.

Purpose of the Study:

  • To highlight the diagnostic complexities of SAPHO syndrome.
  • To underscore the importance of clinical and imaging investigations in differentiating SAPHO from other conditions.

Main Methods:

  • Review of clinical presentations and diagnostic approaches for SAPHO syndrome.
  • Analysis of potential etiopathogenic factors including infectious, immunologic, and genetic components.

Main Results:

  • SAPHO syndrome presents with a spectrum of symptoms, often requiring extensive differential diagnosis.
  • Etiopathogenesis is multifactorial, likely involving Propionibacterium acnes, immune dysregulation, and genetic predisposition.

Conclusions:

  • Accurate diagnosis of SAPHO syndrome necessitates comprehensive clinical evaluation and advanced imaging.
  • Treatment strategies are tailored to individual patient symptoms, drawing from case reports and small series data.