Related Experiment Video
Updated: May 12, 2026
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Correlation of risk scores with coronary anatomy in non-ST-elevation acute coronary syndrome
Elizabete Silva dos Santos1, Luciano de Figueiredo Aguiar Filho, Daniela Menezes Fonseca
1Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil. elizabetessantos@cardiol.br
Insights
Risk scores correlate with coronary lesion severity in acute coronary syndrome. The TIMI risk score demonstrated the strongest predictive ability for identifying significant coronary lesions.
Area of Science:
- Cardiology
- Medical Diagnostics
- Clinical Risk Assessment
Background:
- Limited research exists on the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS).
- This study focuses on non-ST elevation ACS patients.
Purpose of the Study:
- To correlate established risk scores with the severity of coronary artery lesions in patients with non-ST elevation acute coronary syndrome.
- To evaluate the predictive ability of TIMI and GRACE risk scores in identifying significant coronary lesions (≥ 50%).
Main Methods:
- Analysis of 582 patients with non-ST elevation ACS between July 2004 and October 2006.
- Spearman's non-parametric correlation was used to assess the relationship between TIMI and GRACE (hospital and 6-month) risk scores and coronary lesion severity (≥ 50%).
- Logistic regression analysis and Receiver Operating Characteristic (ROC) curves were employed to determine the predictive accuracy of each score.
Main Results:
- A positive correlation was found between all assessed risk scores and the presence of coronary lesions ≥ 50%.
- The TIMI risk score exhibited the highest correlation (r = 0.363, p < 0.0001).
- The TIMI score also demonstrated the best predictive ability (Area Under ROC Curve = 0.704, p < 0.0001), outperforming both hospital GRACE (0.623) and 6-month GRACE (0.562) scores.
Conclusions:
- Risk scores are significantly correlated with the severity of coronary artery lesions in ACS patients.
- The TIMI risk score is a more effective predictor of significant coronary lesions compared to the GRACE risk scores in this population.
Background:
The literature lacks studies regarding the correlation between risk scores and coronary anatomy in acute coronary syndrome (ACS) OBJECTIVE: Correlate risk scores with the severity of the coronary lesion in ACS with non-ST elevation.
Methods:
A total of 582 patients were analyzed between July 2004 and October 2006. The correlation between TIMI risk scores and GRACE (hospital and six months) scores was performed for patients with coronary lesion ≥ 50%, using Spearman's non-parametric method. Multiple regression logistics was used to determine the predictive ability of the scores to discriminate to discriminate who will have a coronary lesion ≥ 50%.
Results:
Most subjects were male (319 or 54.8%), mean age of 59.9 (± 10.6) years. A positive correlation was observed between risk scores and coronary lesion ≥ 50% (TIMI r = 0.363 [p < 0.0001]; hospital GRACE r = 0.255 [p < 0.0001]; GRACE at six months r = 0.209 [< 0.0001]). The area under the ROC curve for each score to determine to discriminate who will have a coronary lesion > 50% was: TIMI = 0.704 [CI95% 0.656-0.752; p <0.0001]; hospital GRACE = 0.623 [CI95% 0.573-0.673; p < 0.0001]; GRACE at six months= 0.562 [CI95% 0.510-0.613; p ;= 0.0255]. Comparing the areas under the ROC curve, it was found: TIMI versus hospital GRACE: p = 0.01; TIMI versus GRACE at six months:p < 0.0001; hospital GRACE versus GRACE at six months: p = 0.0461.
Conclusion:
Risk scores correlate with the severity of coronary lesions, and the TIMI risk score showed the best predictive ability.
More Related Videos
06:16Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
06:57Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images
Published on: September 22, 2023
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Coronary Artery Disease I: Introduction
01:26Acute Coronary Syndrome V: Nursing Management