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Related Experiment Video

Updated: May 12, 2026

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

[Sclerosing encapsulating peritonitis after peritoneal dialysis].

Alexandre Tagliari Cestari¹, Marina Lourenço de Conti, João Antonio Gonçalves Garreta Prats

¹Faculdade de Ciências Médicas de Santos, Fundação Lusíada, Santos, SP, Brasil.

Jornal Brasileiro De Nefrologia

|April 20, 2013

Summary

Sclerosing encapsulating peritonitis (SEP) is a rare complication of long-term peritoneal dialysis (PD). This condition involves fibrous tissue replacing the peritoneum due to hypertonic dialysate exposure, leading to intestinal issues.

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Area of Science:

Nephrology
Gastroenterology
Pathology

Background:

Peritoneal dialysis (PD) is a crucial renal replacement therapy for chronic renal failure.
Patients undergoing PD are susceptible to various treatment-related complications.
Long-term exposure to hypertonic dialysate can lead to peritoneal complications.

Observation:

A rare case of sclerosing encapsulating peritonitis (SEP) is presented in a patient with chronic renal failure on PD.
The patient experienced multiple PD complications, including bacterial peritonitis, tertiary hyperparathyroidism, and cholelithiasis.
After eight years of PD, the patient developed intestinal sub-occlusion and decreased ultrafiltration, necessitating a switch to hemodialysis.

Findings:

The diagnosis of sclerosing encapsulating peritonitis (SEP) was confirmed.
Histopathological changes revealed gradual replacement of the peritoneum by fibrous tissue.
The patient's symptoms significantly improved with corticotherapy, suggesting stabilization of SEP.

Implications:

This case highlights SEP as a rare but serious long-term complication of peritoneal dialysis.
Early recognition and management, including potential transfer to hemodialysis and corticotherapy, are crucial.
Further research into the pathogenesis and prevention of SEP in PD patients is warranted.