Related Experiment Video

Updated: May 12, 2026

Diffusion Imaging in the Rat Cervical Spinal Cord
10:46

Diffusion Imaging in the Rat Cervical Spinal Cord

Published on: April 7, 2015

Diffusion-weighted MRI in assessment of renal dysfunction

Ankur Goyal1, Raju Sharma, Ashu S Bhalla

  • 1Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi, India.

The Indian Journal of Radiology & Imaging
|April 20, 2013
PubMed
Abstract

Insights

Apparent diffusion coefficient (ADC) values from diffusion-weighted MRI can help detect renal dysfunction and chronic kidney disease (CKD) severity. Lower ADC values indicate poorer kidney function.

Area of Science:

  • Radiology
  • Nephrology
  • Medical Imaging

Background:

  • Diffusion-weighted magnetic resonance imaging (DW-MRI) is an emerging technique for assessing renal diseases.
  • The full potential of DW-MRI in nephrology is still under investigation.

Purpose of the Study:

  • To investigate the correlation between apparent diffusion coefficient (ADC) values in the renal parenchyma and markers of kidney function.
  • To assess the relationship between ADC values and the stage of chronic kidney disease (CKD).

Main Methods:

  • Retrospective analysis of adult patients undergoing DW-MRI for renal lesions.
  • Comparison of renal parenchyma ADC values between patients with normal and impaired renal function.
  • Correlation analysis between ADC values and serum creatinine, blood urea, and estimated glomerular filtration rate (eGFR).

Main Results:

  • Patients with renal dysfunction exhibited significantly lower ADC values compared to those with normal renal function.
  • A significant inverse correlation was observed between ADC values and serum creatinine and blood urea levels.
  • A significant positive linear correlation was found between ADC values and eGFR.
  • ADC values demonstrated a decreasing trend with advancing stages of CKD.

Conclusions:

  • Apparent diffusion coefficient (ADC) values derived from DW-MRI show promise as a non-invasive biomarker.
  • ADC values may aid in identifying the presence and severity of renal dysfunction and CKD.
Keywords:
Apparent diffusion coefficientchronic kidney diseasediffusion-weighted MRIkidneyrenal dysfunction

More Related Videos

Transcutaneous Assessment of Renal Function in Conscious Rodents07:18

Transcutaneous Assessment of Renal Function in Conscious Rodents

Published on: March 26, 2016

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...