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Diffusion Imaging in the Rat Cervical Spinal Cord
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Diffusion-weighted MRI in assessment of renal dysfunction.

Ankur Goyal1, Raju Sharma, Ashu S Bhalla

  • 1Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi, India.

The Indian Journal of Radiology & Imaging
|April 20, 2013
PubMed
Summary

Apparent diffusion coefficient (ADC) values from diffusion-weighted MRI can help detect renal dysfunction and chronic kidney disease (CKD) severity. Lower ADC values indicate poorer kidney function.

Keywords:
Apparent diffusion coefficientchronic kidney diseasediffusion-weighted MRIkidneyrenal dysfunction

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Area of Science:

  • Radiology
  • Nephrology
  • Medical Imaging

Background:

  • Diffusion-weighted magnetic resonance imaging (DW-MRI) is an emerging technique for assessing renal diseases.
  • The full potential of DW-MRI in nephrology is still under investigation.

Purpose of the Study:

  • To investigate the correlation between apparent diffusion coefficient (ADC) values in the renal parenchyma and markers of kidney function.
  • To assess the relationship between ADC values and the stage of chronic kidney disease (CKD).

Main Methods:

  • Retrospective analysis of adult patients undergoing DW-MRI for renal lesions.
  • Comparison of renal parenchyma ADC values between patients with normal and impaired renal function.
  • Correlation analysis between ADC values and serum creatinine, blood urea, and estimated glomerular filtration rate (eGFR).

Main Results:

  • Patients with renal dysfunction exhibited significantly lower ADC values compared to those with normal renal function.
  • A significant inverse correlation was observed between ADC values and serum creatinine and blood urea levels.
  • A significant positive linear correlation was found between ADC values and eGFR.
  • ADC values demonstrated a decreasing trend with advancing stages of CKD.

Conclusions:

  • Apparent diffusion coefficient (ADC) values derived from DW-MRI show promise as a non-invasive biomarker.
  • ADC values may aid in identifying the presence and severity of renal dysfunction and CKD.