Post-orchidectomy retroperitoneal seminoma: A case report

Area of Science:

• Oncology
• Urology
• Pathology

Background:

• Malignant germ cell tumors (GCTs) rarely occur at extragonadal sites, accounting for 2-5% of male GCTs.
• The precise origin of extragonadal retroperitoneal GCTs is debated, with ongoing discussion about primary development versus metastasis from an occult testicular primary.
• Undescended testes are associated with an increased risk of GCTs.

Purpose of the Study:

• To present a case of retroperitoneal seminoma in a patient with a history of orchidectomy for an undescended testis.
• To contribute to the discussion regarding the origin of extragonadal germ cell tumors.

Main Methods:

• Case report of a 38-year-old male patient.
• Review of patient's medical history, including prior orchidectomy.
• Diagnostic workup for retroperitoneal mass, including histopathological examination.

Main Results:

• Diagnosis of retroperitoneal seminoma was established.
• Patient had a history of right orchidectomy 10 years prior for an undescended testis, with initial histology reported as a benign inflammatory mass.
• The case raises questions about the potential for occult testicular GCTs or transformation of previously benign lesions.

Conclusions:

• This case underscores the complexity in determining the origin of extragonadal retroperitoneal germ cell tumors.
• It highlights the importance of thorough long-term follow-up for patients with a history of undescended testes and prior testicular surgery.
• Further research is needed to elucidate the pathogenesis of these rare tumors.