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Antibodies to interleukin 2 in sera of autoimmune-prone mice
M Tabata1, K Kobayashi, S Kaga
1First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Scandinavian Journal of Rheumatology
|January 1, 1990
Abstract:
Autoimmune-prone mice spontaneously develop the disease characterized by autoantibodies to a wide variety of antigens. In the present study, we have demonstrated that IgG antibodies to interleukin 2 (IL-2) are to be found in serum of autoimmune mice in association with ageing. These antibodies can neutralize the biological activity of IL-2 and thus play an important role in the etiopathogenesis of autoimmune disease.