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Related Experiment Video

Updated: May 12, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Expert consensus building using e-Delphi for necrotizing enterocolitis risk assessment.

Sheila M Gephart1, Judith A Effken, Jacqueline M McGrath

  • 1College of Nursing, The University of Arizona, P.O. Box 210203, Tucson, AZ 85721, USA. sgephart@nursing.arizona.edu

Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
|April 23, 2013
PubMed
Summary
This summary is machine-generated.

The GutCheck(NEC) risk index for necrotizing enterocolitis (NEC) in premature infants achieved borderline content validity. Expert consensus varied on NEC risk factors and treatment impacts, highlighting areas for future refinement.

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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
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Related Experiment Videos

Last Updated: May 12, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
08:42

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Area of Science:

  • Neonatalogy
  • Clinical Informatics
  • Pediatric Research

Background:

  • Necrotizing enterocolitis (NEC) is a significant concern in premature infants.
  • Accurate risk assessment is crucial for timely intervention and improved outcomes.
  • Existing risk indices require validation and expert consensus.

Purpose of the Study:

  • To confirm the content validity of the GutCheck(NEC) risk index.
  • To determine expert agreement on risk factors for NEC in premature infants.
  • To refine the GutCheck(NEC) tool for clinical utility.

Main Methods:

  • An electronic Delphi (e-Delphi) method was employed.
  • Online surveys and email communication facilitated expert input from 35 nurses and physicians across four countries and the US.
  • Qualitative thematic analysis of expert comments guided consensus building over three survey rounds.

Main Results:

  • The GutCheck(NEC) index retained 43 items representing 33 risk factors, achieving a Content Validity Index (CVI) of .77.
  • Key themes included individual physiologic vulnerability and variations in neonatal intensive care unit (NICU) clinical practices.
  • Disagreements emerged regarding the impact of treatments like probiotics, packed red blood cell (PRBC) transfusions, and patent ductus arteriosus (PDA) management.

Conclusions:

  • GutCheck(NEC) demonstrated borderline content validity, indicating potential as a new risk assessment scale.
  • The e-Delphi process revealed both consensus and divergence among experts on NEC risk factors.
  • Further research is planned to optimize the risk index for clinical application and assess its reliability.