Related Experiment Video

Updated: May 12, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Transcriptional network of androgen receptor in prostate cancer progression

Ken-ichi Takayama1, Satoshi Inoue

  • 1Department of Anti-Aging Medicine, The University of Tokyo, Tokyo, Japan.

International Journal of Urology : Official Journal of the Japanese Urological Association
|April 23, 2013
PubMed

Insights

Androgen receptor signaling drives prostate cancer growth. Understanding its downstream effects is key to treating castration-resistant prostate cancer and identifying new therapeutic targets.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The androgen receptor (AR) is a nuclear receptor and transcription factor crucial for prostate cancer development.
  • AR signaling drives prostate cancer cell proliferation, and AR blockade is a primary therapy.
  • Progression to castration-resistant prostate cancer (CRPC) involves elevated AR expression and hypersensitivity.

Purpose of the Study:

  • To elucidate the diverse transcriptional programs regulated by androgen receptor in prostate cancer.
  • To identify AR-regulated genes that serve as prognostic markers or therapeutic targets for CRPC.

Main Methods:

  • Utilized comprehensive analysis tools including complementary DNA microarray, chromatin immunoprecipitation-on-chip, and chromatin immunoprecipitation-sequence.
  • Conducted functional and clinical studies on AR-regulated genes.

Main Results:

  • Characterized androgen-mediated transcriptional programs and gene networks in prostate cancer.
  • Identified several AR-regulated genes with potential as prognostic markers and therapeutic targets for CRPC.

Conclusions:

  • Identifying AR downstream signaling events is critical for understanding prostate cancer carcinogenesis and CRPC progression.
  • AR-regulated genes represent promising avenues for novel CRPC therapies.
Keywords:
androgen receptorcastration-resistant prostate cancergenomic medicineprostate cancertranscription

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