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Functional Imaging of Viral Transcription Factories Using 3D Fluorescence Microscopy
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Redefining KSHV latency.

Ohad Yogev1, Chris Boshoff

  • 1Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Huntley Street, University College London, London WC1E 6BT, UK.

Cell Host & Microbe
|April 23, 2013
PubMed
Summary
This summary is machine-generated.

Kaposi's sarcoma-associated herpesvirus uniquely infects lymphatic endothelial cells (LECs), activating mTORC1 signaling. This infection sensitizes LECs, but not blood endothelial cells (BECs), to rapamycin, due to a specific virus latency program.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic human herpesvirus.

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