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Redefining KSHV latency
1Cancer Research UK Viral Oncology Group, UCL Cancer Institute, Huntley Street, University College London, London WC1E 6BT, UK.
Cell Host & Microbe
|April 23, 2013
Abstract:
In this issue of Cell Host & Microbe, Chang and Ganem (2013) report that Kaposi's sarcoma-associated herpesvirus infection of lymphatic endothelial cells (LECs), but not blood endothelial cells (BECs), activates mTORC1 signaling and sensitizes LECs to rapamycin-induced killing. The differential rapamycin sensitivity is explained by a unique LEC-specific virus latency program.

