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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
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Cancer Therapies

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Related Experiment Video

Updated: May 12, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Mechanism-based therapeutic approaches to cachexia.

Fabio Penna1, Gabriella Bonelli, Francesco M Baccino

  • 1Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.

Vitamins and Hormones
|April 23, 2013
PubMed
Summary

Cachexia, a syndrome of body weight and muscle loss, involves inflammation and metabolic changes. This review explores novel therapeutic strategies targeting these underlying mechanisms for better patient outcomes.

Related Experiment Videos

Last Updated: May 12, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Area of Science:

  • Biomedical science
  • Metabolic research
  • Clinical nutrition

Background:

  • Cachexia is a complex syndrome causing significant weight loss, muscle depletion, and metabolic dysfunction.
  • It severely impacts patient morbidity, mortality, and quality of life.
  • Key mechanisms include inflammation, anorexia/malnutrition, and altered protein/lipid metabolism.

Purpose of the Study:

  • To review therapeutic options for cachexia based on underlying mechanistic alterations.
  • To consider nutritional, anti-inflammatory, and signal transduction pathway-targeting strategies.

Main Methods:

  • Literature review of preclinical and clinical studies on cachexia treatments.
  • Focus on therapies addressing specific pathophysiological mechanisms.
  • Analysis of strategies targeting signal transduction pathways.

Main Results:

  • Several therapeutic approaches are under investigation, with some in clinical trials.
  • Nutritional and anti-inflammatory strategies remain important.
  • Targeting specific signal transduction pathways shows promise.

Conclusions:

  • Understanding cachexia mechanisms is crucial for developing effective treatments.
  • A multi-faceted approach combining nutritional, anti-inflammatory, and pathway-specific interventions is needed.
  • Further research and clinical trials are essential to validate novel therapeutic strategies.