Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Migration00:53

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TTC7A deficiency: A retrospective international study on treatment and outcomes from the Inborn Errors Working Party of EBMT.

Journal of human immunity·2026
Same author

Targeting SYK to alleviate MDSC-driven immunosuppression and augment anti-PD1 efficacy.

Science China. Life sciences·2026
Same author

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease.

The New England journal of medicine·2026
Same author

Reshaping study design for faster extrapolation-based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN-NASPGHAN position paper.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia.

Nature communications·2025
Same author

Plasma lipopolysaccharide levels predict mortality in acutely ill children in Low- and Middle-Income Countries.

Nature communications·2025

Related Experiment Video

Updated: May 12, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

ILC1 populations join the border patrol.

Kevin J Maloy1, Holm H Uhlig

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK. kevin.maloy@path.ox.ac.uk

Immunity
|April 23, 2013
PubMed
Summary

Researchers have identified a new type of immune cell, called innate lymphoid cell 1 (ILC1), that is present in inflamed intestines. These T-bet(+)IFN-γ(+) ILC1 cells may be counterparts to T helper 1 cells.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • The existence of an innate lymphoid cell (ILC) counterpart to the T helper 1 (Th1) cell lineage has remained an open question in immunology.
  • T helper 1 cells are critical for cell-mediated immunity and host defense against intracellular pathogens.

Discussion:

  • This study identifies a distinct ILC subset, termed ILC1, characterized by the expression of T-bet and IFN-γ.
  • These ILC1 cells were found to accumulate in the inflamed intestinal tissue of patients suffering from inflammatory bowel disease (IBD).

Key Insights:

  • The identification of T-bet(+)IFN-γ(+) ILC1 provides evidence for an innate lymphoid cell lineage analogous to Th1 cells.
  • The presence of ILC1 in inflamed IBD intestines suggests a potential role in intestinal inflammation and immunity.

More Related Videos

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
10:23

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

Related Experiment Videos

Last Updated: May 12, 2026

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
10:25

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

Published on: September 20, 2019

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry
09:02

Isolation of Uterine Innate Lymphoid Cells for Analysis by Flow Cytometry

Published on: October 14, 2021

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations
10:23

Single-cell Gene Expression Using Multiplex RT-qPCR to Characterize Heterogeneity of Rare Lymphoid Populations

Published on: January 19, 2017

Outlook:

  • Further research is warranted to elucidate the precise functions and regulatory mechanisms of ILC1 in intestinal homeostasis and disease.
  • Understanding ILC1 biology may offer new therapeutic targets for inflammatory bowel disease and other immune-mediated conditions.