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Updated: May 12, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian
Fabiana Barzotti Kohlrausch1, Clarissa Severino-Gama, Maria Inês Lobato
1Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói, Brazil. fabianabk@yahoo.com
Abstract:
We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine. We found the *1F/*1F genotype to be significantly associated with seizures, and no relationship was observed with combinations of *1F and *1C alleles.
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