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Related Experiment Video

Updated: May 12, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

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Published on: April 21, 2015

CD39 and CD73 in immunity and inflammation.

Luca Antonioli1, Pál Pacher, E Sylvester Vizi

  • 1Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.

Trends in Molecular Medicine
|April 23, 2013
PubMed
Summary

The CD39 and CD73 enzymes regulate immune cell signaling by converting ATP to adenosine, shifting environments from inflammatory to anti-inflammatory. Targeting this pathway offers potential treatments for diseases like cancer and autoimmune disorders.

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Published on: June 24, 2020

Area of Science:

  • Immunology
  • Biochemistry
  • Pharmacology

Background:

  • CD39 and CD73 are ectoenzymes crucial for purinergic signaling.
  • They sequentially convert adenosine triphosphate (ATP) to adenosine.
  • This conversion modulates immune cell responses and tissue microenvironments.

Purpose of the Study:

  • To elucidate the role of the CD39/CD73 pathway in immune regulation.
  • To explore the therapeutic potential of targeting CD39 and CD73 in various diseases.

Main Methods:

  • Enzymatic activity assays.
  • Immune cell functional assays.
  • Pathophysiological model analysis.

Main Results:

  • The CD39/CD73 pathway dynamically regulates the balance between pro-inflammatory (ATP) and anti-inflammatory (adenosine) signals.
  • Altering CD39/CD73 activity impacts disease progression in models of AIDS, autoimmune diseases, infections, atherosclerosis, ischemia-reperfusion injury, and cancer.

Conclusions:

  • The CD39/CD73 pathway is a key regulator of immune homeostasis.
  • Targeting CD39 and CD73 represents a promising therapeutic strategy for a range of disorders.