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The iron link between malaria and invasive non-typhoid Salmonella infections

Susanne van Santen1, Quirijn de Mast, Dorine W Swinkels

  • 1Department of General Internal Medicine, Nijmegen Institute for International Health (456), Radboud University Medical Center, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

Trends in Parasitology
|April 23, 2013
PubMed

Insights

Malaria infections increase iron in immune cells, potentially boosting survival of invasive non-typhoid Salmonella (NTS). Further research is needed to determine if iron supplementation exacerbates this risk in malaria-endemic areas.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Nutritional Immunology

Background:

  • Epidemiological studies show a link between malaria and invasive non-typhoid Salmonella (NTS) infections, particularly in children.
  • Iron dysregulation is implicated in infectious disease susceptibility and severity.

Purpose of the Study:

  • To explore the role of iron as a cofactor in the association between malaria and invasive NTS infections.
  • To investigate the impact of malaria-induced inflammation on macrophage iron content and Salmonella survival.

Main Methods:

  • Review of epidemiological data linking malaria and NTS.
  • Analysis of mechanisms involving erythrophagocytosis and inflammation in malaria.
  • Hypothesizing the role of iron in intracellular Salmonella survival.

Main Results:

  • Malaria is associated with increased erythrophagocytosis and inflammation.
  • These processes elevate iron levels within macrophages.
  • Elevated macrophage iron may enhance the survival of Salmonella species.

Conclusions:

  • Iron may act as a critical cofactor in the malaria-NTS infection association.
  • Iron supplementation programs in malaria-endemic regions warrant careful consideration.
  • Further research is crucial to understand the global health implications of iron status in malaria-coinfected populations.

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