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Updated: May 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

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Published on: March 14, 2017

Numerous granulocyte transfusions to a patient with severe aplastic anemia without severe complication

Ikbal Ok Bozkaya1, Abdurrahman Kara, Nese Yarali

  • 1Department of Pediatric Hematology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey. ikbalok@yahoo.com

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|April 23, 2013
PubMed

Insights

Granulocyte transfusions are crucial for managing invasive fungal infections in severe aplastic anemia patients, even with antifungal resistance. This case study highlights their safety and efficacy, with only mild fever as a complication.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Oncology

Background:

  • Invasive fungal infections (IFIs) are a major cause of morbidity in aplastic anemia.
  • Neutrophils are critical for controlling IFIs, but their levels are severely reduced in aplastic anemia.
  • Antifungal therapies alone are often insufficient for IFIs in immunocompromised patients.

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