Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

Vascular Spasm

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intradialytic nutritional intake and adherence perspective of a national and continuous meal model in a large hemodialysis patient cohort.

Clinical nutrition (Edinburgh, Scotland)·2026

Same author

Midazolam prescription as a trigger for potential deceased donor identification outside the ICU: a prospective feasibility study.

BMC palliative care·2026

Same author

An ontology-based description of nano computed tomography measurements in electronic laboratory notebooks.

Scientific data·2026

Same author

EPIGAME a vignette-based study of management practices of medication overuse in migraine, among French neurologists.

Revue neurologique·2026

Same author

Migraine management in France: Practices of general practitioners and neurologists.

Revue neurologique·2025

Same author

Analysis of maturation dynamics and oocyte nuclear quality after rescue-IVM and semi-automated vitrification.

Human reproduction (Oxford, England)·2025

Search research articles

Related Experiment Video

Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

[Migraine and vascular risk].

E Guegan-Massardier¹, C Lucas

¹Service de neurologie, unité neurovasculaire, hôpital Charles-Nicolle, CHRU de Rouen, 76038 Rouen cedex, France. Evelyne.massardier@chu-rouen.fr

Revue Neurologique

|April 23, 2013

Summary

Migraine with aura increases ischemic stroke risk, especially for smokers using oral contraceptives. While the exact cause is unknown, managing vascular risks in migraine patients is crucial.

Area of Science:

Neurology
Cardiology
Vascular Medicine

Background:

Migraine with aura is a known risk factor for ischemic stroke.
Migraine is linked to silent brain infarcts, white matter lesions, and potentially coronary artery disease.
The pathophysiology of increased ischemic events in migraineurs remains unclear.

Purpose of the Study:

To review the association between migraine and cerebrovascular and cardiovascular diseases.
To explore potential pathophysiological mechanisms linking migraine to vascular events.
To provide guidance on vascular risk management in migraine patients.

Main Methods:

Literature review of studies investigating migraine and vascular risks.
Analysis of neuroimaging findings (MRI) in migraine patients.

More Related Videos

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Related Experiment Videos

Last Updated: May 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

Examination of epidemiological data on stroke, cardiovascular disease, and mortality in migraineurs.

Main Results:

Migraine with aura significantly elevates ischemic stroke risk, particularly in smokers and oral contraceptive users.
Migraineurs exhibit higher prevalence of silent brain infarcts and cerebral white matter lesions.
Associations with coronary artery disease and cervical artery dissection are noted; mortality data are controversial.
Endothelial dysfunction and prothrombotic states are potential contributing factors.

Conclusions:

Migraine, particularly with aura, is associated with increased risks of ischemic stroke and other vascular events.
Risk factors like smoking and oral contraceptive use exacerbate these risks.
Primary vascular prevention strategies for migraineurs are similar to the general population, with specific avoidance recommendations for certain individuals.