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Updated: May 12, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models
Yanni Xiao1, Hongyu Miao, Sanyi Tang
1School of Mathematics & Statistics, Xi'an Jiaotong University, Shaanxi, China.
Abstract:
We review mathematical modeling and related statistical issues of HIV dynamics primarily in response to antiretroviral drug therapy in this article. We start from a basic model of virus infection and then review a number of more advanced models with consideration of pharmacokinetic factors, adherence and drug resistance. Specifically, we illustrate how mathematical models can be developed and parameterized to understand the effects of long-term treatment and different treatment strategies on disease progression. In addition, we discuss a variety of parameter estimation methods for differential equation models that are applicable to either within- or between-host viral dynamics.
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