Related Experiment Video
Updated: May 12, 2026

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
Published on: November 16, 2016
Virulence aspects of Listeria monocytogenes LO28 high pressure-resistant variants
Ineke K H Van Boeijen1, Pat G Casey, Colin Hill
1Top Institute Food and Nutrition (TIFN), P.O. Box 557, 6700 AN Wageningen, The Netherlands.
Abstract:
High pressure treatment is a novel food processing approach for reducing pathogens in foods and food ingredients. However, relatively little is known about the pathogenic potential of organisms that survive the treatment. Twelve previously isolated and characterized variants of Listeria monocytogenes LO28 obtained after a high pressure treatment were assessed for their virulence potential and antibiotic susceptibility. Ten variants showed attenuated virulence while two variants retained full virulence in a mouse model of infection. Seven of the attenuated variants demonstrated a reduction in virulence factor activity. Compared to the wild type, all variants exhibited similar or increased susceptibility to multiple antibiotics commonly used in listeriosis treatment.
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