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Cimetidine-associated adverse reaction.

E J Drea¹, A H Mutnick, W Lam

¹Department of Pharmacy Services, Memorial Medical Center, Springfield, IL 62781.

DICP : the Annals of Pharmacotherapy

|June 1, 1990

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Intravenous cimetidine can cause adverse reactions like bradycardia and hypotension, even without rapid infusion. This reaction was confirmed by rechallenge in a patient, highlighting a rare but serious side effect.

Area of Science:

Pharmacology
Clinical Medicine
Cardiology

Background:

Cimetidine, a histamine2-receptor antagonist, is widely used for peptic ulcer disease.
It is generally considered safe with few reported adverse reactions.

Observation:

A case report details an adverse reaction to intravenous cimetidine.
The reaction included junctional rhythm, bradycardia, and hypotension.

Findings:

The adverse reaction was not attributed to rapid infusion of cimetidine.
The reaction was reproducible upon rechallenge with the drug.
This specific adverse reaction profile has not been clearly defined or confirmed in prior literature.

Implications:

Related Experiment Videos

This case highlights a potentially serious, albeit rare, adverse effect of intravenous cimetidine.

Clinicians should be aware of this potential cardiovascular side effect.

Further investigation may be warranted to understand the mechanism and prevalence of this reaction.