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Oxybutynin-induced reflux esophagitis.

M Lee¹, R Sharifi

¹College of Pharmacy, University of Illinois, Chicago 60612.

DICP : the Annals of Pharmacotherapy

|June 1, 1990

Summary

Oxybutynin, often preferred for its lower anticholinergic effects, can paradoxically cause reflux esophagitis by relaxing the lower esophageal sphincter. This case highlights a rare adverse effect of oxybutynin and informs management strategies.

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Area of Science:

Gastroenterology
Pharmacology

Background:

Oxybutynin is frequently prescribed for overactive bladder due to its reduced anticholinergic activity compared to propantheline bromide.
Patients at risk for anticholinergic adverse effects are often candidates for oxybutynin therapy.

Observation:

A case of oxybutynin-induced reflux esophagitis is presented.
The adverse effect is hypothesized to stem from oxybutynin's anticholinergic properties, specifically its impact on lower esophageal sphincter (LES) tone.

Findings:

Oxybutynin's anticholinergic action can lead to decreased lower esophageal sphincter tone.
This mechanism can precipitate gastroesophageal reflux disease (GERD) symptoms, manifesting as reflux esophagitis.

Implications:

Clinicians should consider reflux esophagitis as a potential adverse effect of oxybutynin.
A management approach for oxybutynin-induced esophagitis and similar medication-induced GERD is outlined for clinical practice.

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